Posted By admin on February 24, 2013
A study, done over 10 years, consisting of over 35,000 Danish women who had been hospitalised due to endometriosis has found that there is a significantly higher risk of Crohn’s disease.
The study concludes that where Endometriosis has been surgically verified, the risk of having Crohn’s disease is 80% higher than those without. Where the diagnosis had not been confirmed surgically (symptom only diagnosis) the risk was 50% higher than the normal population. The study was undertaken from 1997 to 2007, the women were then followed up for up to 13 years, 320 of the women developed Inflammatory Bowel Disease and 92 with Crohn’s disease.
Crohn’s disease generally causes complications within the gastrointestinal tract, including diarrhoea, vomiting and weight loss.
The study was led by Dr. Tine Jess and a team of researchers at the Statens Serum Institute in Copenhagen, Denmark.
BMJ journal Gut article:
Posted By admin on June 12, 2011
A study undertaken over several years has indicated that the most extensive form of Endometriosis may be predicted by the severity of menstrual periods in teenage girls.
The extensive form of Endometriosis is know as “Deep Infiltrating Endometriosis” (DIE). There are three distinct forms of Endometriosis (not to be confused with different stages/levels): Superficial Endometriosis, Ovarian Endometriosis and Deep Infiltrating Endometriosis. DEep Infiltrating Endometriosis is the most extensive, women with this condition will usually have extensive deposits of Endometriosis leading to adhesions in multiple parts of the body, including the vagina, bladder and ligaments that attach the uterus to the pelvis.
It is not unusual for several years (or longer) to go before a woman is diagnosed with Endometriosis due to the difficulty in diagnosis (the only reliable way is still a laproscopy and direct examination of the endometrium cells) and the number of diseases that can be similar to Endometriosis or may present at a similar time due to complications. However the study, undertaken by Dr Charles Chapron and colleagues included nearly 230 women who had surgery at a medical center between 2004 and 2009, of these 43% had DIE and the rest had the less extensive forms (Ovarian and Superficial).
During the study symptoms and histories were taken, this has led to a general conclusion (however more studies are needed from multiple sources to confirm or to enable more firm conclusions) that women who suffered from more painful periods and were prescribed birth control pills to treat this pain were more likely to suffer from DIE. Such evidence could lead to faster diagnosis of this severe type of Endometriosis.
However the study also concluded that any advance in diagnosis would not prevent the eventual progression to this invasive form of Endometriosis.
Original article source content (for the purposes of brevity this has been interpreted and re-written)
SOURCE: http://link.reuters.com/xam46q Fertility and Sterility, online November 11, 2010.
Posted By MedWire News - Ob/Gyn on July 5, 2010
Women with endometriosis are significantly less productive at work compared with women without the disease, say UK-based researchers. (Source: MedWire News – Ob/Gyn)
Posted By American Journal of Reproductive Immunology on July 3, 2010
Conclusion Our results suggest that the IL-10 ACC/ACC genotype, which is known to be a ‘low-producer’ of IL-10, is associated with endometriosis. (Source: American Journal of Reproductive Immunology)
Posted By The Doctors Lounge - Health News on July 2, 2010
Here are factors that may increase your risk (Source: The Doctors Lounge – Health News)
Posted By BioMed Central on July 1, 2010
The objective of this study was to develop and validate a daily electronic Endometriosis Pain and Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis symptoms from the patient’s perspective in a clinical trial setting.
The EPBD items were developed based on clinician input and the results of 5 focus groups (N=38) and 3 iterative sets of cognitive interviews (N=22). The psychometric properties were evaluated using data collected in a usual-practice, non-intervention study conducted at 4 sites in the United States. Existing questionnaires were also administered to explore the construct validity of the EPBD. The development and validation processes were consistent with the recommendations in the 2009 FDA Patient Reported Outcomes Guidance to Industry.
Posted By Archives of Pathology and Laboratory Medicine on June 30, 2010
CONCLUSIONS: The correlation between original FS and WSI interpretations was very high. The few discordant cases represent recognized differential diagnostic issues. Ability to examine gross pathology and real-time consultation with surgeons might be expected to improve performance. Ovarian FS diagnosis by WSI is accurate and reproducible, and thus, remote interpretation, teaching, and digital archiving of ovarian FS specimens by this method can be reliable.
PMID: 20586631 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Posted By Journal of Pineal Research on June 30, 2010
Abstract: The role of matrix metalloproteinases (MMPs) in endometriosis, a gynecological disease of women, is unclear. The study investigated the activity of MMP-3 and its interplay with MMP-9 during the onset of endometriosis. Additionally, the importance of MMP-3 on the apoptotic pathway in endometriosis and effect of melatonin thereon were investigated. A Significant increase in the activity of MMP-3 with the severity of endometriosis in human was observed which was found similar in mice also. During the early phase of endometriosis, MMP-3 but not MMP-9 was increased and associated with the expression of transcription factor, c-Fos. Moreover, urokinase plasminogen activator and tissue inhibitor of metalloproteinase (TIMP)-3 were involved in MMP-3 regulation during endometriosis. Further…
Posted By Health News from Medical News Today on June 29, 2010
The first worldwide study of the societal impact of endometriosis has found a significant loss of work productivity among those women who suffer from the condition, a researcher told the 26th annual meeting of the European Society of Human Reproduction and Embryology. Dr. Kelechi Nnoaham, from the Department of Public Health, University of Oxford, UK, said that the results of this multi-centre study would help highlight the previously unrecognised plight of an estimated 176 million women around the world whose lives are affected by endometriosis… (Source: Health News from Medical News Today)
Posted By EurekAlert! - Medicine and Health on June 28, 2010
(European Society of Human Reproduction and Embryology) The first worldwide study of the societal impact of endometriosis has found a significant loss of work productivity among those women who suffer from the condition. (Source: EurekAlert! – Medicine and Health)