Endometriosis: Risk factor for ovarian cancer?
Posted By MayoClinic.com Full Feed on June 23, 2010
Endometriosis and ovarian cancer are linked, but the relationship isn’t straight cause and effect. (Source: MayoClinic.com Full Feed)
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Identification and Quantification of Dopamine Receptor 2 in Human Eutopic and Ectopic Endometrium: A Novel Molecular Target for Endometriosis Therapy.
Posted By Biology of Reproduction on June 22, 2010
Authors: Novella-Maestre E, Carda C, Ruiz-Sauri A, Garcia-Velasco JA, Simon C, Pellicer A
Previous studies in an experimental mice model of endometriosis have shown that the dopamine agonist (DA) cabergoline (Cb2) reduces angiogenenesis and endometriotic lesions, hypothetically binding to the dopamine receptor type-2 (DRD2). To date, this has not been described in human endometrium and/or endometriotic lesions. Thus, we aimed to investigate the presence of DRD2 in said tissues. Endometrium fragments were implanted in nude mice treated with different doses of Cb2. PCR assays and immunohistochemistry were performed to analyze the gene and protein expression (respectively) of DRD2, VEGF and VEGF receptor-2 (KDR). In addition, lesions and endometrium from women with mild and severe endomet…
Endometriosis
Posted By New England Journal of Medicine on June 22, 2010
A healthy 25-year-old woman presents with worsening dysmenorrhea, new-onset left lower quadrant pain, and dyspareunia. She has regular menstrual cycles, and her last menstrual period was 3 weeks before presentation. How should this patient be evaluated and treated? (Source: New England Journal of Medicine)
CME: Endometriosis
Posted By New England Journal of Medicine on June 22, 2010
(No abstract is available for this citation) (Source: New England Journal of Medicine)
[Neurotrophins and pain in endometriosis.]
Posted By Gynecologie, Obstetrique et Fertilite on June 22, 2010
CONCLUSION AND DISCUSSION: This is the first study reporting an over-expression of all neurotrophins in endometriosis, as only NGF was previously documented. It confirms the central role of this family in the genesis and modulation of pain in endometriosis. Anti-neurotrophin selective therapy might be a promising way of analgesia in the future.
PMID: 20579920 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)
[Surgical treatment of tubo-ovarian abscess occurring in deep endometriosis.]
Posted By Gynecologie, Obstetrique et Fertilite on June 22, 2010
We report six cases of patients presenting tubo-ovarian abscesses arising on deep endometriosis, and we discuss the choice of the 2-step surgical management. In four cases, deep endometriosis resection has been performed by laparoscopic route few months after the drainage of abscess and provided macroscopically complete excision of the disease.
PMID: 20579921 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)
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Pain and Endometrioma Recurrence after Laparoscopic Treatment of Endometriosis: A Long-Term Prospective Study
Posted By The Journal of Minimally Invasive Gynecology on June 22, 2010
This study, out of Rome, Italy, studied 166 consecutive women in a prospective observational fashion over a 6-year time period, with recruitment ending in June 2004, followed by at least 3 years follow-up. All patients had unilateral or bilateral endometriomas (mean size 4.9 cm) treated by laparoscopic cystectomy. Fifty-seven percent had American Fertility Society Classification of Endometriosis stage III, and 43% had stage IV disease. The mean age was 31.5 years, and the most common complaint was pain (76.5%). (Source: The Journal of Minimally Invasive Gynecology)
Robot-Assisted Laparoscopic Presacral Neurectomy: Feasibility, Techniques, and Operative Outcomes
Posted By The Journal of Minimally Invasive Gynecology on June 22, 2010
Conclusion: Robot-assisted laparoscopic presacral neurectomy is feasible and safe, without added risk of short- or long-term complications. It compares favorably to the conventional laparoscopic approach of presacral neurectomy. The surgical robot provides a better angle and 3-dimensional visualization of the operating field, similar to laparotomy, and supplemented with magnification. This combined with elimination of hand tremor enables better surgeon control. (Source: The Journal of Minimally Invasive Gynecology)
IVF unaffected by adenomyosis in women with endometriosis
Posted By MedWire News - Ob/Gyn on June 21, 2010
Research results indicate that the presence of adenomyosis in women with endometriosis has no adverse effect on IVF/intracytoplasmic outcomes. (Source: MedWire News – Ob/Gyn)
Abbott And Neurocrine Announce Global Agreement To Develop And Commercialize Elagolix For The Treatment Of Endometriosis
Posted By Health News from Medical News Today on June 17, 2010
Abbott and Neurocrine Biosciences, Inc. announced they have entered into a collaboration agreement to develop and commercialize elagolix for the treatment of endometriosis-related pain. Elagolix is a novel, first-in-class oral gonadotropin-releasing hormone (GnRH) antagonist, which has recently completed a phase IIb study in endometriosis. In addition to endometriosis, elagolix will be evaluated for the treatment of uterine fibroids… (Source: Health News from Medical News Today)