[Establishment of serum peptidome pattern-based diagnostic model of endometriosis.]
Posted By Journal of Southern Medical University on March 31, 2010
Authors: Li LA, Wang N, Liang TT, Li AL, Li YL
OBJECTIVE: To establish a diagnostic model of endometriosis by analyzing serum peptidome patterns in patients with endometriosis using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). METHODS: Serum samples from 21 endometriosis patients and 29 healthy control subjects were analyzed using MALDI-TOF-MS and Clinprotools 2.0 software to establish the diagnostic model of endometriosis, which was validated using the serum samples from 10 endometriosis patients and 15 healthy controls. RESULTS: Eighteen statistically significant peptide peaks were obtained with the m/z value ranging from 1 000 to 10 000 (P<0.01). Among the peaks, 12 were down-regulated and 6 up-regulated. The sensitivity and specifi…
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